After starting out in TV and B-movies, George Clooney has established himself as one of Hollywood's biggest stars. Let's take a look at the Oscar-winner's career so far.
Clooney got his start in TV, appearing in shows like the short-lived sitcom "E/R," "Roseanne," "Hotel," "The Golden Girls" and "Facts of Life" in the mid-to-late-1980s.
One of the earliest roles he's known for is 1988's B-movie sequel "Return of the Killer Tomatoes!"
He continued getting small parts in TV shows until he landed the role of Dr. Doug Ross in the NBC drama "ER." The role launched him to fame and he spent nearly five years on the show before leaving in 1999.
Clooney and his fellow "ER" cast members pose with their Screen Actors Guild awards for best ensemble of a dramatic television series on Feb. 22, 1997.
Even while acting on "ER," Clooney found time to try his hand at movies, starting with 1996's vampire flick "From Dusk Till Dawn."
As one of his moonlighting roles, Clooney had the misfortune of starring in 1997's widely reviled "Batman & Robin," better known for the bat suit's nipples and cod piece than any of its acting.
Arnold Schwarzenegger and Clooney unveil Schwarzenegger's Mr. Freeze costume from "Batman & Robin" on June 6, 1997, in Planet Hollywood in Beverly Hills.
Clooney's role as bank robber Jack Foley opposite Jennifer Lopez in 1998's "Out of Sight" was better received.
Clooney makes a point as he accepts the GQ Men of the Year award for Television Actor at New York's Radio City Music Hall on Oct. 21, 1998.
In 1999 he broke free of "ER" with the Gulf War drama "Three Kings," co-starring Ice Cube and Mark Wahlberg.
"O Brother, Where Art Thou?," the Coen Brothers' 2000 take on Homer's "Odyssey," gave Clooney the chance to have the best-reviewed performance of his career to that point.
The "O Brother" role earned him the Golden Globe for Best Performance by an Actor in a Motion Picture - Comedy/Musical in 2001.
He followed the role up with "The Perfect Storm," a small role in "Spy Kids," and "Ocean's 11," the first in what would become a trilogy of "Ocean's" movies.
Clooney poses with Mark Wahlberg, his co-star in "The Perfect Storm," at the movie's premiere on June 26, 2000, in Los Angeles.
In 2002, Clooney stepped behind the camera for his directorial debut, taking on "Confessions of a Dangerous Mind" with Drew Barrymore and Sam Rockwell.
Clooney and his then-girlfriend, model Lisa Snowden, arrive at the "Ocean's Twelve" Hollywood premiere on Dec. 8, 2004.
In 2005, he tackled the role of CIA agent Bob Barnes in the politically-charged drama "Syriana."
The role won Clooney the Oscar for Best Supporting Actor in 2006.
He received two more Oscar nominations (Best Original Screenplay and Best Director) in 2006 for "Good Night, and Good Luck," his second stint as a director.
Clooney also began to get more involved in causes. Here he speaks on the Make Poverty History campaign at a news conference near the G8 summit in Scotland on July 6, 2005.
With the U.S. Capitol as a backdrop, Clooney speaks at the "Million Voices for Darfur" rally on April 30, 2006.
In 2006, he tackled the role of American military journalist Jake Geisner in "The Good German," co-starring Tobey Maguire and Cate Blanchett.
Clooney poses at the Los Angeles premiere of "The Good German" on Dec. 4, 2006.
He received his first Best Actor Oscar nomination, and fourth overall nomination, for 2007's "Michael Clayton."
Clooney puts his hands in cement in front of Grauman's Chinese Theatre in Los Angeles on June 5, 2007.
In January 2008, Clooney was designated a UN Messenger of Peace, joining eight other well-known individuals to campaign for UN causes.
Brad Pitt and Clooney pose on the red carpet for a showing of "Burn After Reading" at the Venice Film Festival on Aug. 27, 2008.
2009 was a busy year for Clooney with "Up in the Air," "Fantastic Mr. Fox" and "The Men Who Stare At Goats."
His "Up in the Air" role earned him his second Best Actor Oscar nomination, his fifth nod from the Academy Awards.
Clooney and girlfriend Elisabetta Canalis arrive at the 67th annual Golden Globe Awards in Beverly Hills on Jan. 17, 2010.
Clooney smiles during an interview with Reuters in Southern Sudan's capital of Juba on Jan. 8, 2011.
Clooney's played an assassin in 2010's "The American."
Clooney plays a presidential candidate in the political drama "The Ides of March." Clooney also directed the film, which marks the fourth time he's stepped behind the camera.
Director and cast member George Clooney poses at the premiere of "The Ides of March" at the Samuel Goldwyn Theatre in Beverly Hills, Calif., on Sept. 27, 2011.
In December 2011, Clooney starred in "The Descendants," playing a land baron attempting to re-connect with his two daughters (including Shailene Woodley) after his wife is seriously injured in a boating accident.
His role in "The Descendants" won Clooney a Golden Globe. He's seen here posing in the photo room at the 69th annual Golden Globe Awards on Jan. 15, 2012. Clooney also received an Oscar nomination for the role.
Clooney and his girlfriend, Stacy Keibler, pose on the red carpet as they arrive at the 84th Academy Awards in Hollywood, Calif., on Feb. 26, 2012.
Clooney testifies before the Senate Foreign Relations Committee on March 14, 2012, about violence in Sudan.
Clooney and then-girlfriend Stacy Keibler arrive at the 70th annual Golden Globe Awards in Beverly Hills, Calif., Jan. 13, 2013.
A bearded Clooney arrives at the 85th Academy Awards in Hollywood, Calif., on Feb. 24, 2013.
Clooney poses with his fellow "Argo" producers Grant Heslov and Ben Affleck after the movie won Best Picture at the 85th Academy Awards.
In 2013 Clooney teamed up with long-time friend Sandra Bullock in the space thriller "Gravity."