Published On: Feb 14 2012 10:21:24 AM ESTUpdated On: May 06 2015 10:57:30 AM EDT
Clooney got his start in TV, appearing in shows like the short-lived sitcom "E/R," "Roseanne," "Hotel," "The Golden Girls" and "Facts of Life" in the mid-to-late-1980s.
One of the earliest roles he's known for is 1988's B-movie sequel "Return of the Killer Tomatoes!"
He continued getting small parts in TV shows until he landed the role of Dr. Doug Ross in the NBC drama "ER." The role launched him to fame and he spent nearly five years on the show before leaving in 1999.
Even while acting on "ER," Clooney found time to try his hand at movies, starting with 1996's vampire flick "From Dusk Till Dawn."
As one of his moonlighting roles, Clooney had the misfortune of starring in 1997's widely reviled "Batman & Robin," better known for the bat suit's nipples and cod piece than any of its acting.
Clooney's role as bank robber Jack Foley opposite Jennifer Lopez in 1998's "Out of Sight" was better received.
In 1999 he broke free of "ER" with the Gulf War drama "Three Kings," co-starring Ice Cube and Mark Wahlberg.
"O Brother, Where Art Thou?," the Coen Brothers' 2000 take on Homer's "Odyssey," gave Clooney the chance to have the best-reviewed performance of his career to that point.
He followed the role up with "The Perfect Storm," a small role in "Spy Kids," and "Ocean's 11," the first in what would become a trilogy of "Ocean's" movies.
In 2002, Clooney stepped behind the camera for his directorial debut, taking on "Confessions of a Dangerous Mind" with Drew Barrymore and Sam Rockwell.
In 2005, he tackled the role of CIA agent Bob Barnes in the politically-charged drama "Syriana."
He received two more Oscar nominations (Best Original Screenplay and Best Director) in 2006 for "Good Night, and Good Luck," his second stint as a director.
In 2006, he tackled the role of American military journalist Jake Geisner in "The Good German," co-starring Tobey Maguire and Cate Blanchett.
He received his first Best Actor Oscar nomination, and fourth overall nomination, for 2007's "Michael Clayton."
2009 was a busy year for Clooney with "Up in the Air," "Fantastic Mr. Fox" and "The Men Who Stare At Goats."
His "Up in the Air" role earned him his second Best Actor Oscar nomination, his fifth nod from the Academy Awards.
Clooney's played an assassin in 2010's "The American."
Clooney plays a presidential candidate in the political drama "The Ides of March." Clooney also directed the film, which marks the fourth time he's stepped behind the camera.
In 2013 Clooney teamed up with long-time friend Sandra Bullock in the space thriller "Gravity."
In 2014, George Clooney directed and starred in "The Monuments Men."