Sullivan County sheriff's detectives acting on a tip searched the home of Angela Robinette on Kincaid Street in Kingsport.
They say they found hundreds of pills, including what was believed to be Adderall, Xanax, and Percocet.
Detectives say they also found drugs on James Robinette at the same address. Both were arrested.
Detectives also arrested Matthew Thomas and Juan Eduardo Rojas after the two men pulled into Robinette's driveway.
Detectives say drugs were found on them as well.